Here's the latest from Ausiello at TVGuide.com:

My 21st birthday is today and, aside from a good drink, I would like nothing more than some scoop on Grey's Anatomy. Please tell me that Callie will find out soon about George and Izzie whoring around behind her back?

Poor Callie will remain blissfully unaware until around, um, let's go with May 10. The following week, I believe the smelly brown stuff hits the fan.
Is Isaiah Washington leaving Grey's Anatomy?

If he is, ABC is doing a really good job of keeping a lid on it. This much I know for sure: At the end of next Thursday's episode, Burke starts to have some serious reservations about marrying Cristina. And you're never going to believe whom he turns to for advice. (Hint: They had a little dust-up at the Golden Globes.)
On Grey's, will Jane Doe get an actual identity before the end of the season?

I hear she's getting an actual hubby in the season finale, so it stands to reason that her identity is part of the package.
It seems that, on Grey's Anatomy, Mark's "failure" to go 60 days without sex must mean, dare I say it, that he's unable to have sex? Am I right?

Nope. I suggest you hunt down someone by the name of Christine Frickle for the answer to this brainteaser. She was the only AA reader who figured out what I meant by "failure." Congratulations, Christine!