Here's the all-new and amazing description from ABC on the fourth season of Grey's Anatomy...and it looks like we'll be picking up two weeks after the finale "Didn't We Almost Have It All?"

Entering their first year as residents after passing their intern exams, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new crop of interns are George (forced to repeat his internship after failing his exams) and Lexie Grey, Meredith’s half-sister.

Overseeing the residents is the newly-appointed Chief Resident, Callie Torres. With the no-nonsense Miranda Bailey earning the interns’ respect over the past year, the new residents are finding it difficult to report to someone else, particularly George’s wife.

Bailey, who is displeased with Dr. Webber after he chose Callie for Chief Resident over her, must find her bearings within the hospital pecking order. While she finds her footing, Webber resumes his position as Chief of Surgery, doing his best to maintain a work/life balance for the sake of his recently-reunited marriage.

Two weeks after being left by her fiancé on her wedding day, Cristina returns to the hospital from her honeymoon accompanied by Meredith, who badly needed an escape of her own after her relationship with Derek Shepherd hit an emotional impasse. Cristina relies on what she always has – her ability as a surgeon – to cope with the break-up.

Mark Sloan wishes to renew his friendship with his old friend, Derek, who could sorely use a friend after Addison’s move, Burke’s resignation and his rocky relationship with Meredith.

The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis – it’s in one another that they find comfort, friendship and, at times, more than friendship. Together they’re discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.