Well, that was fast. Right after posting the below post, I ran across this bit of info from SpoilerFix.com, and boy is it freakin' exciting:

• I'm hearing [that George and Callie's relationship] is proving quite a difficult puzzle for Shonda Rhimes, who is fully aware of the fan backlash over last season's George and Izzie hookup and has been doing quite a few rewrites.
• Executives tied to the show say the fourth-season plan is to add several cast members, including at least one fresh-faced new intern: Meredith Grey's half-sister Lexi (Chyler Leigh) will become a frequent presence with a multi-episode story arc. They are also seeking a new recurring male character to compete with Patrick Dempsey's Dr. McDreamy.
• Clara, who is with her two young children, discuss the status of her husband Henry with one of the doctors. Henry has suffered extremely traumatic injuries during a car accident. The doctor says that the only thing holding Henry's head to his body is skin and muscle and that he will surely died very soon, even with surgery. A boy brings a near-dead racoon to Seattle Grace in the hope they will be able to save it. His father wants his son to grow up and stop living in a make-believe world. Some of the doctors need to deal with new stressed out interns. One of the interns will help deliver a baby.

The episode? Well, it's titled A Change is Gonna Come, which is freakin' fitting, don't you think? It also makes me wonder...is Gizzie off? This is all very confusing and I CANNOT WAIT!