According to Kristin from E! Online, McSteamy and Izzie are on.

McNo!! Why??? WHY??? WHY??

Sometimes I really do wonder what Denny did to that poor girl's mind. Hopefully it won't be another Meredith/George-like incident, though. Who knows, maybe McSteamy and Izzie will actually be - yes, I'm going to say it - a cute, happy couple.