Here's all the scoop from Shonda Rhimes herself, thanks to those wonderful people over at TVGuide - this time, it's the magazine. The issue? It's currently on stands now. Grey's Anatomy returns April 24.

What's next "When we come, we'll have leapt ahead five or six weeks in time," creator Shonda Rhimes says. "It's our way of acknowledging the bump [caused by the strike]. But it'll be very clear from the first moment what has transpired. You'll see where things stand with Derek and Meredith and Rose. You'll see where George is living, and in the first episode all the residents will be involved in a high-stakes surgical contest - definitely something the chief would not condone."
Hookup central "Old relationships will become new again, some people you thought would never get together will, and there are going to be some interesting outside influences," Rhimes promises. George and Izzie have "put it to bed for the night. They've left it at the idea that it's not necessarily about the bad sex as [it is] the bad timing. What will be interesting to see is that after the intimate explosion of events [whether] they can just be friends." Pretty boy plastic surgeon Mark "McSteamy" Sloan will continue his pursuit of hard-to-impress Dr. Hahn. "The way that is going to play out will be surprising to everyone," Rhimes says. "Mark is not used to not getting what he wants."
The MerDer Chronicles "I am pretty dedicated to the idea that they are going to be together for good this season," Rhimes says. "What's going to be interesting is how she gets her act together, and how they decide this is it." Are those wedding bells we hear?! "I did not say there is going to be a wedding," Rhimes says. "Or a ring. Although I didn't say there wasn't going to be a ring."
Flamethrower Addison will pop up at Seattle Grace to perform surgeries that only she can do and "discover whether you can really ever go home," Rhimes says.

Ausiello posted a bit of new stuff on Grey's today, and while it's more speculation from the actors than anything, we'll take it in a time where we've got nothing. Enjoy!

I've been in a slump ever since that last Grey's Anatomy episode. Could you make a girl's day a little brighter and give her a little poop? I chatted up Sara Ramirez at the SAGs and she hinted that Callie might not be in a rush to jump back into another steady relationship post-George. "I think it's an interesting concept, Callie being alone again. It's a universal issue that women deal with a lot. 'What do I do when I'm alone?' 'Is it OK to be alone and not have a man?' I think it's an interesting thing to explore. But, you know, it's Grey's Anatomy. And we love our hookups and one-night stands. I'm all for her finding love in all the wrong places all over again. Maybe there's more than one? She should play the field a little."
I loved the last original Grey's Anatomy episode — especially the Alex-Izzie moments. Have you heard any scoop about them getting together next season? I have not, but Justin Chambers had some very interesting things to say about that very subject at the SAG Awards. "I think Alex has a deep longing for her," he told me. "He's just not man enough to admit it. He's got a lot of issues to work out. Hopefully he'll get secure enough with them."

Here the results to our latest poll! - Who will get fired? - which garnered 134 votes.

• 85 said Callie will get fired.
• 2 said Cristina will get fired.
• 2 said Meredith will get fired.
• 0 said Bailey will get fired.
• 5 said Izzie will get fired.
• 40 said someone else will get fired.

Check out this awesome news from TVGuide.com:

Spin-off shmin-off. Let's talk Grey's Anatomy proper. The popular rom-dram may — just may — wash away its Season 3 backstage troubles and on-screen waterski-flirtations with a May wedding for Christina and Burke. Judging by pics and sightings shared at JustJared, Katherine Heigl's Izzie is suited up as a bridesmaid, while Ellen Pompeo appears to be the Mer of honor. The spied scenes, though, are merely from a bridal-shop try-on session for Yang & Co., so will the vow-swap actually go off without a hitch? Or will Roger Rees pull a Benjamin Braddock? Eww, I don't need to see that.

Here's the newest Grey's scoop from Ausiello at TVGuide.com:

Please, please, please tell me that Izzie is on the pill.

Do I look like her personal pharmacist to you? Do I?! But while we're on the subject of contraceptives, before the season is over, one character will discover that she has no need for 'em — and hasn't for some time. (Any self-respecting member of AA should know exactly who I'm referring to.)
As one of the few supporters of Team Gizzie on Grey's Anatomy, is there any hope? I'm sick of Callie!

Yes, it appears there's a glimmer of hope. Sigh….
I know you hate the Izzie-George hookup, but you have to admit, that scene between them in the closet was perfection.

Yeah, that much I'll give ya.
Please stop referring to the Grey's Anatomy spin-off as "the enhanced two-hour Grey's Anatomy episode with a potential for afterlife." It wasn't even funny the first time, so just imagine how amusing it is now.

Can I just do it one more time? Pleeease?!?!

Here's the newest Kristin scoop, straight from E! Online:

Is the Torres family involved in the Grey's spin off? Hector Elizondo is playing Callie's dad on Grey's, and he was announced as part of the Grey's 2.0 cast.
According to my sources, this got muddled up in the media. Yes, Hector does play Callie's dad, and yes, he is in the spinoff setup episode, but no, Hector is not involved in the spinoff itself, as had been reported in many outlets. So, Mr. O'Malley and Addison are not running away together. And as I reported in this week's Vine show, she'll have her eye on the sexed up receptionist, Sean Faris from Life as We Know It. (Also known as Tom Cruise's dreamy doppleganger.)
Was there a "moment" there between Mer and Mark in the scrub room on Grey's?! Please say it ain't so.
As far as I know, it ain't so! I'm told Meredith and Derek will be going strong for a good, long while. The death of someone very close to Meredith brings MerDer closer together—and tears her apart (again) from her father.
Are George and Izzie really in love?
They're 100 percent smitten, from what I hear. And, yes, that is a two-way street. There are also rumblings that Sara Ramirez (Callie) might not be coming back as a series regular next season—but I think Izzie started those.
I saw your latest Vine show, and I'm so happy Cristina and Burke are headed for the altar! Is she really going to wear a poofy dress?
Yep. Despite her insistence on city hall, I'm told they'll have a full-on traditional wedding with the big dress and bridesmaids and everything—at the insistence of both her mother and Burke's mother.

Here's the newest scoop on Grey's Anatomy from Michael Ausiello at TVGuide.com:

Izzie and George — noooooooooooooooooo!

My thoughts exactly. BTW, don't forget to check out my urgent news bulletin regarding tomorrow night's Grey's. Your life depends on it.
My birthday was last Friday, just like your BFF Lauren Graham! That should be worth some serious Grey's scoop.

Lucky for you, I just received a fresh batch of intel regarding the enhanced two-hour May-sweeps episode of Grey's Anatomy with a potential for afterlife (aka the spin-off). According to multiple unnamed spies who (lucky for us) can't keep their traps shut, Addison comes to the conclusion that (Spoiler alert) McSteamy is about a decade away from becoming father material, and hightails it to Los Angeles to meet with one of the world's foremost fertility experts. Mrs. Egg Harvester is also one of Addison's BFFs and the owner of a state-of-the-art wellness center, which just so happens to be looking for a neonatal specialist. I think you can figure out the rest.
OK, totally hated the George-Izzie hookup on Grey's last week. That was the last thing I thought was true from your list of twists. I had money on Burke's transfer!

Funny thing is, one of the "false" plots twists nearly turned out to be true — and it still might! I got a questionable tip about two weeks ago that (Potential spoiler alert) Callie was pregnant, and Grey's was planning to set up a whole "Who's the daddy?" story with George and McSteamy. But now it looks like that was another Shonda Rhimes-tested and -approved foiler.
So George and Izzie actually happened on Grey's Anatomy. I guess you gave us fair warning. Now can you please assure us that it was a one-time drunken mistake and it won't be happening again?

I really wish I could. But I can't.
I heard on the radio that Lisa Kudrow may also join the Grey's spin-off. Have you heard anything about this?

Not true. Lisa was up for one of the primary roles — Amy Brenneman's part, perhaps? — but apparently a return to TV prompted this reaction from her: "I don't want to see that!" (Never gets old.)

Monday brings all-new Michael Ausiello scoop on Grey's Anatomy from TVGuide.com, so be sure to check it out below:

I was hoping that Izzie and George hooking up would be one of the false plot twists in your Grey's Anatomy tease last month (Ask Ausiello 2/21). But I just saw the preview for tomorrow's episode and I'm freaking out. Please tell me it's some kind of mistake.
Let me just say this: After tomorrow's Grey's airs, you'll know which one of the six plot twists is real. Here they are again in case you're too lazy to click on the link above.

• After breaking things off with Cristina, Burke will transfer to another hospital.
• Callie will reveal she's pregnant.
• Izzie and George will hook up.
• Izzie will be reunited with her daughter, and it's someone we've already seen on the show.
• Addison will be diagnosed with a life-threatening illness.
• Derek and Meredith's relationship will hit a roadblock when one of her exes shows up on her doorstep with one thing on his mind.

So why did Grey's Anatomy put the kibosh on the Addison and Alex romance?

I hear the brakes were put on Addisex the moment it was decided that Justin Chambers wouldn't be following Kate Walsh over to Grey's 2.0. The thinking being: no sense in getting viewers even more invested in Addisex if only one of 'em is returning to Seattle Grace next season.

So, any scoop on which females (other than Kate Walsh, of course) will be featured on Grey's 2.0? We've already got several hunky males signed up.
Sounds like someone forgot to check in on the Ausiello Report this week.

I am devastated that Shonda Rhimes has put Jeffrey Dean Morgan’s journalist show on the back burner. Can you confirm if this is set for the summer or if it has been canceled altogether?

ABC insists it's still in play, but word on the street is it's as good as dead. And that's especially true if Grey's 2.0 gets off the ground — which, let's face it, it will.

Here's the latest on Grey's from Kristin at E! Online:

Any Grey's scoop? Please! Are Cristina and Burke actually gonna do it?
Ummm...yes, I'm pretty sure they have already played dirty doctor and naughty nurse, if you catch my drift. But if you're talking about taking the plunge and becoming man and wife, well, it doesn't look likely! Sources tell me that Cristina will soon realize that the only reason she said yes was for him. And by the time the intern-on-intern action goes down, I'm told the Cristina and Burke may be on the outs.

I saw your latest Vine show, and I'm aghast. Gizzie? It is happening?
Did my facial expression not give it away? Don't make me spell it out for you. Don't make Shonda Rhimes come and kick my ass.

Check out the promo for Thursday's all-new episode of Grey's Anatomy here and prepare to be - well - GROSSED OUT! According to the promo (which, God help us all, please let it be misleading), Izzie and George will be hooking up next Thursday. Will this be a repeat of Merge last season? Or will Gizzie actually be a happy couple? Honestly, I'm interested, but still...Izzie and George?!

It's that day again - Monday! Which means more Kristin scoop on Grey's Anatomy! Enjoy!

Will Loretta Devine be making any more appearances on Grey's before the season is over? I won't accept that this is the end of the road for the chief and his Adele. Especially now since Ellis is dead!
I totally just ran into the divine Loretta Devine at the Independent Spirit Awards and asked her if she'd be back on Grey's after slamming the door in the chief's face. She said, "I hope so…like the chief wasn't cheating! They don't let you know ahead of time what's going to happen, but I hope she comes back."

Grey's Anatomy! Who's going to hook up?
Addison and McSteamy. And Izzie and...oh, I can't tell you that! I might be wanting to die today, but on most other days I do like my life.

Yah, that's it next week. Who could Izzie be hooking up with? God, don't let it be George. Please. We're all begging you!

Here's a hot-off-the-press spoiler from Kristin from E! Online's newest chat:

I heard that the little girl seen this season on Grey's who felt no pain was supposed to turn out to be the daughter that Izzie put up for adoption. Any truth to this?
Funny. Do you think that rumor was started because the little girl was sort of a Claire from Heroes? Anyhoo, I had not heard that, and I also know that casting agents have been in Toronto recently, looking to cast a girl between the ages of 10 and 12 for an arc next season. Now, as much as a great show like Grey's might plan ahead, this seems to be way ahead, if you ask me. So, my first thought is that this girl is Izzie's bio-daughter.

According to Kristin from E! Online, McSteamy and Izzie are on.

McNo!! Why??? WHY??? WHY??

Sometimes I really do wonder what Denny did to that poor girl's mind. Hopefully it won't be another Meredith/George-like incident, though. Who knows, maybe McSteamy and Izzie will actually be - yes, I'm going to say it - a cute, happy couple.