According to the official Grey's Anatomy website, the Season Five premiere will be on Thursday, September 25. At the present time, there is no other information on the premiere, and most likely there won't be until at least the end of next month. Here's the neat little synopsis that ABC wrote, however:

The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis. It's in one another that they find comfort, friendship and, at times, more than friendship.

Probably due to the fact that the episode isn't finished yet (I've had this confirmed by ABC), the final pre-strike episode (the one with no production involvement and completed completely by the network) Lay Your Hands on Me has been pushed back from January 3 to January 10. Haunt You Every Day will now air on January 3. Stay tuned as more updates come in.

According to our affiliate, SpoilerTV, episode 409 Crash Into Me is part one of two, and is airing on Thanksgiving (despite rumors Grey's would be in repeats that Thursday). Now, ABC hasn't issued a press release yet, so this isn't confirmed. So, take it with a grain of salt. Here's what they've got:

Part 1 of 2. Meredith and the Chief struggle to save paramedics injured in an ambulance crash; Bailey treats a patient who refuses her help; Ava (Elizabeth Reaser) returns to see Alex---and meets his new girlfriend.

Airs: 22nd November 2007

Source: SpoilerTV

As per ABC, the September 27th return of Grey's Anatomy with "A Change is Gonna Come," is not set in stone quite yet. While, yes, it is the expected return date for the show, the network has not yet officially decided if that is the date or not (however, most likely it will be). We'll be sure to let you know when the date is confirmed, if it is.

Here's an interesting tidbit of news that I ran across when reading either People or InTouch this morning: according to the magazine, Shonda Rhimes is actually really good friends with Isaiah Washington, and fought for his job on the show. I can believe that to an extent. What I can't believe is this next part: Shonda is contemplating creating a show just for Isaiah. And...that was the extent of the article. Can I just say that Shonda's already got enough under her belt with one hit show, another show premiering in the fall, and yet another show placed on the backburner (where it's been for...years)? Plus, she'd have to travel to a different network for this show, because Lord knows ABC won't work with Isaiah again, and vice versa. I'm hoping that this magazine is, well, wrong.
Here's the more exciting news: the anticipated return date for Grey's is September 27. This isn't confirmed and could be changed (and I wouldn't be surprised...it seems really late - however, a late start means less re-runs). The show goes back into production sometime this month, so details surrounding the new season (including the title of the premiere, air date, promotional photos and videos) should begin surfacing within the next six weeks, so stay tuned!

According to the podcast information, Grey's Anatomy will return with it's final few episodes of the season on April 19th, with the premiere of Time After Time (which was originally known as Ain't Nothing But The Real Thing). Mark your calendars!

According to numerous rumors all over the web, the next episode - My Favorite Mistake - which was originally supposed to air on March 29, may actually air on March 22 - this upcoming Thursday! According to these reports, ABC wants to keep the Grey's lead-in on October Road, since it did MUCH better than Six Degrees when it premiered. However, nothing yet has been confirmed by ABC. Although the official website says it is airing on the 22nd, ABC Media Net is still reporting it's airdate as the 29th. Stay tuned for more updates on this!
(Also - My Favorite Mistake is not the spin-off episode as previously reported. That episode, which has yet to be titled, will be two hours long and is currently set to air on May 10th.)

UPDATE [6:54 PM]: A source on the ABC Message Boards e-mailed ABC to ask them, and here's the reply they got back -

The episode was originally scheduled to air March 29, but it should air on the 22nd now.

Best,
Amy Astley
ABC Media Relations

So, there you have it. My Favorite Mistake will be airing on March 22, 2007.

Flying around the web today is a supposed airing schedule for the rest of Grey's current season. It's obviously not completely correct (ie My Favorite Mistake is one episode, but two hours, and therefore counted as two seperate episodes - but they're most likely airing at the same time unlike Six Days), but, here it is anyways, just so you can see it and plan accordingly. And, according to this, the season finale is set for May 17. Mark your calendars (but only in pencil)!

March 15: Episode 318 Scars and Souvenirs
March 22: Episode 319 My Favorite Mistake
March 29: rerun
April 5: rerun
April 12: Special Clip Show Every Moment Counts
April 19: Episode 320 Time After Time
April 26: Episode 321 Desire
May 3: Episode 322-323 [spin-off episode]
May 10: Episode 324
May 17: Episode 325 (Season Finale)

Updated on March 11, 2007 based off new information.
Updated once again on March 18, 2007 based off new information.
Updated again on March 23, 2007 based off new information

So, if you've checked out Grey's Gossip lately, you've probably seen some pretty terrible rumors. The first one broke a few days ago, claiming that the cast is furious with Kate Walsh for getting her own show - especially Ellen Pompeo. Now, nothing much else has been said on this rumor as of yet, but most fans think it's pretty much just that - a rumor. I mean, really, why would EP be upset? She's already the star of her own show!
Onto the next one. This one has been resolved already, but, just to let you know. This rumor started earlier this week, and it was stating that Katherine Heigl was upset about how she wasn't getting paid as much as Sandra Oh or Isaiah Washington, and was in talks to drop out of her contract. Today, however, ABC Television Studios (fka Touchstone Televsion) released a press release, brought to you here by our good 'friend' Kristin at E! Online:

Katherine is an integral part of Grey's Anatomy and its success. Fortunately, we have a long-term contract [six more years] to ensure she'll be with the show for several years to come. In recognition of her tremendous talent and value to the show, we recently approached Katherine with an offer to raise her compensation significantly above the terms of her current contract. We were surprised to see this gesture reported negatively in the press, and want to reassure fans that she will continue as Izzie Stevens.

So there you have it!

Also, here's some other Grey's news for you about the spin-off. The episode that will serve as the pilot for the as-of-yet untitled spin-off, My Favorite Mistake, will be a two-hour episode that will serve as this season's 22nd and 23rd episodes (and not the 19th, as earlier indication said), making it the final episode to air before the Season 3 Finale. And don't worry - if Addison's Anatomy falls through, or gets cancelled, Addison will be flown right back to Seattle Grace and rejoin the docs of Grey's Anatomy.

Check out two back-to-back repeats of two great episodes of Grey's Anatomy tonight on ABC!
At 9/8c, it's Season 3 Episode 9 "From a Whisper to a Scream" followed by Season 3 Episode 10 "Don't Stand So Close to Me" at 10/9c. And next week, be sure to check out an all-new episode of Grey's Anatomy - Season 3 Episode 11 "Six Days."
And this Sunday at 11pm EST, be sure to watch Grey's from the beginning and watch Season 1 Episode 1 "A Hard Day's Night" on Lifetime!

Here's the current GREYschedule up until January 18th:

December 14th
Season 3 Episode 4 "What I Am"

December 21st
Season 3 Episode 5 "Oh, the Guilt"

December 28th
Season 3 Episode 6 "Let the Angels Commit"

January 4, 2007
Season 3 Episode 9 "From a Whisper to a Scream"

January 11, 2007 (tentative)
Season 3 Episode 11 "Six Days (Part One)"

January 18, 2007 (tentative)
Season 3 Episode 11 "Six Days (Part Two)"

More information, including confirmation on the Six Days possible two-parter, coming soon!

Season 3 Episode 11 "Six Days" is apparently not airing until January 11, 2007. Be sure to check out more information in the post below.